Is iTunes still having compatibility issues in Windows Vista?
Apple recommends that iTunes customers using Windows Vista upgrade to iTunes version 7.2 or later to avoid potential problems including Windows operating system corruption.
Ejecting iPod using Windows Explorer on Windows Vista may corrupt your iPod. Please refer to the information below for further details.
Microsoft has released an update for Windows Vista that addresses a situation where ejecting iPod from Windows Explorer or by using the "Safely Remove Hardware" feature in Windows Vista could corrupt your iPod. Apple recommends Windows Vista customers who own an iPod install this software update. For information on how to install this Microsoft hot fix, refer to the "Update your software" section below. Tip: iPod can always be ejected safely by choosing Eject iPod from the Controls menu within iTunes.
Update your Software
Microsoft has made this Update for Windows Vista (KB936824) available via Windows Update as well as a separate download package. To download this update via Windows Update follow the steps below:
From the Start Menu, choose Control Panel.
In Control Panel, select Check for Updates in the Security section. If the Control Panel is in Classic view, open Windows Update.
Click the View Available Updates link and be sure that Update for Windows Vista (KB936824) is checked.
This update can also be downloaded from the following Microsoft support document: